A8674-25MG Display Image

Antimycin A from Streptomyces sp.,

Code: A8674-25MG D2-231

Application

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive p...


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Your Price
£52.70 25MG

Application

Antimycin A has been used to study the specific sites of reactive oxygen species production in mitochondria isolated from skeletal muscle of chronic obstructive pulmonary disease patients, and its relationship with local oxidative stress induced by exercise

Antimycin A from Streptomyces sp. has been used:as a respiratory chain inhibitor in neuronal culturesin organello ATP production assay in Trypanosoma brucei cellsin respiration assay for papillary thyroid carcinoma (PTC) cell lines

Biochem/physiol Actions

Inhibitor of electron transfer at complex III. Induces apoptosis.

General description

Chemical structure: peptide

Antimycin is produced by Streptomyces species. It inhibits mitochondrial electron transport chain complex III and favors reactive oxygen species (ROS) production, impairing mitochondrial depolarization. It inhibits nitric oxide-mediated apoptosis and modulatescytochrome C release. It suppresses tumorigenesis in lung cancer cells and could be a potential therapeutic agent.

Packaging

25, 50, 100 mg in glass bottle

Quality

A mixture of antimycins.

antibiotic activity spectrumfungi
formpowder
InChI keyUIFFUZWRFRDZJC-RBVQMQRASA-N
InChI1S/C28H40N2O9/c1-6-7-8-9-11-20-25(39-22(32)14-16(2)3)18(5)38-28(36)23(17(4)37-27(20)35)30-26(34)19-12-10-13-21(24(19)33)29-15-31/h10,12-13,15-18,20,23,25,33H,6-9,11,14H2,1-5H3,(H,29,31)(H,30,34)/t17-,18+,20?,23+,25+/m1/s1
mode of actionenzyme | inhibits
Quality Level300
SMILES string[H]C(=O)Nc1cccc(C(=O)N[C@H]2[C@@H](C)OC(=O)C(CCCCCC)[C@@H](OC(=O)CC(C)C)[C@H](C)OC2=O)c1O
storage temp.−20°C
Code
Description
Unit Size
List Price
Qty
A8674-50MG
Unit:50MG
List Price: £95.40
Source:List Price
ADD
A8674-100MG
Unit:100MG
List Price: £167.00
Source:List Price
ADD
Cas Number1397-94-0
Hazard Class6.1
Un Number3462
Pack GroupII
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